Synthesis
These are formed by proteolytic cleavage of a big prepropeptide which is the product of the CALC1 factor, which itself is a share of a superfamily of related protein endocrine precusors including Islet Amyloid Precursor Protein, Calcitonin Gene-Related Peptide & the precursor of Adrenomedullin.

Physiology
A endocrine participates within calcium and phosphorus metabolism & it was detected around fish, reptilian, birds & mammalian.

Specifically, thyrocalcitonin reduces blood calcium levels in tierce shipway: decreasing atomic number 20 absorption per intestines decreasing osteoclast activity in bones decreasing atomic number 20 resorption per kidney tubules

Pharmacology
Salmon thyrocalcitonin is utilized for the coarse of action of: postmenopausal osteoporosis hypercalcaemia Paget's disease bone metastases

History
Calcitonaround was purified in 1962 by Copp & Cheney. When it was at first considered the secretion of the parathyroid glands, it wwhen later identified as a secretion of the C-cells (parafollicular cells) of the thyroid gland.